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Immunology of ENT Disorders

Immunology of ENT Disorders PDF Author: Glenis K. Scadding
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 248

Book Description
This book highlights the areas in which immunological mechanisms are now known to be involved in disorders of the ears, nose and throat. These include the normal defence mechanisms of the upper respiratory tract, the immunology of the tonsils and failures of immunity, such as fungal infections, granulomatous disorders and malignancies. Disorders of the middle and inner ear are considered, as are nasal polyposis and various aspects of allergy: allergic rhinitis, and food sensitivity in relation to the nose and allergy. A final chapter deals with the future prospects for immunological involvement in ENT disorders. The volume provides interesting insights, with possible novel therapeutic approaches, not only to otorhinolaryngologists, but also to audiologists, allergists and respiratory physicians. It also provides an up-to-date background for any immunological researcher in this field.

Immunology of ENT Disorders

Immunology of ENT Disorders PDF Author: Glenis K. Scadding
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 248
Book Description
This book highlights the areas in which immunological mechanisms are now known to be involved in disorders of the ears, nose and throat. These include the normal defence mechanisms of the upper respiratory tract, the immunology of the tonsils and failures of immunity, such as fungal infections, granulomatous disorders and malignancies. Disorders of the middle and inner ear are considered, as are nasal polyposis and various aspects of allergy: allergic rhinitis, and food sensitivity in relation to the nose and allergy. A final chapter deals with the future prospects for immunological involvement in ENT disorders. The volume provides interesting insights, with possible novel therapeutic approaches, not only to otorhinolaryngologists, but also to audiologists, allergists and respiratory physicians. It also provides an up-to-date background for any immunological researcher in this field.

Immunology of ENT Disorders

Immunology of ENT Disorders PDF Author: Glenis K. Scadding
Publisher: Springer Science & Business Media
ISBN: 9401114366
Category : Medical
Languages : en
Pages : 230
Book Description
Until recently, the contribution of immunological knowledge to the under standingand management ofENTdisorders was slight, being largely confined to the appreciation that many rhinitic patients were allergic. Happily, this situation is rapidly changing: the immunological basis of many disorders of the ears, nose and throat is becoming recognized and the mechanisms of the reactions involved are being elucidated. From this, rational therapy should evolve. This book aims to highlight some of the areas in which immunological mechanisms are involved in otorhinolaryngology. It is written by experts in their respective fields of immunology and allergy, otology, rhinology and pathology. It opens with an overview ofthe pathways ofthe immune response and the cells and molecules involved, leading to an appreciation of the normal defence mechanisms of the upper respiratory tract and possible areas offailure. There is then a chapter on HIV infection and how this may present to otorhinolaryngologists. The normal function of the tonsil and the immunological effects oftonsillectomy are then considered. The varying roles of fungi in ENT disorders ranging from commensal through allergen to invasive organisms is assessed by Professor R. J. Hay. Perhaps the most obvious immunological contribution to management thus far lies in the immunocytochemical diagnosis of pathological conditions of the ears, nose and throat and this is covered in a chapter by Professor Leslie Michaels.

Immunology of Renal Disease

Immunology of Renal Disease PDF Author: C.D. Pusey
Publisher: Springer Science & Business Media
ISBN: 9401139024
Category : Medical
Languages : en
Pages : 294
Book Description
Although it has been appreciated for many years that immune processes underlie most types of glomerulonephritis, it is the recent explosion in knowl edge of cellular and molecular immunology that has prompted another book on the subject. The understanding of the mechanisms involved in renal injury requires the integration of information from in vitro cell-culture systems, experimental models of disease, and clinical studies. This volume draws on all of these sources in an attempt to explain current concepts of nephritis. Increased emphasis is placed on autoimmune processes, as opposed to the deposition of circulating immune complexes, although it will be apparent that these may overlap in the area of "in situ" immune complex formation. Of central importance in autoimmunity is the relationship between antigen pre senting cells (including B cells) expressing MHC class II molecules, autoan tigenic peptides, T helper lymphocytes, and various effector cells. The mechanisms by which the immune system may lead to tissue injury are also becoming better understood, and consideration is given to the role of inflam matory cells, the complement proteins, and soluble factors such as cytokines and eicosanoids.

Immunology of Gastrointestinal Disease

Immunology of Gastrointestinal Disease PDF Author: T.T. Macdonald
Publisher: Springer Science & Business Media
ISBN: 9401129789
Category : Medical
Languages : en
Pages : 307
Book Description
Gastrointestinal diseases present a considerable problem in human medicine in terms of both morbidity and mortality. The aim of this book is to cover the different immunological disorders of the gut with special reference to immunopathological and protective mechanisms. It will be of general interest to clinicians, scientists and students concerned with the gastrointestinal tract. Topics covered include: the current status of research into toxin-secreting pathogens, Campylobacter, Giardia and HIV; the immunological features of idiopathic inflammatory gut diseases such as Crohn's disease and intractable diarrhoea; the genesis of the flat mucosa; the iatrogenic diseases of the gut such as graft-versus-host disease and small bowel allografts; the immune mechanisms and lesions in the gut of patients with parasitic nematode infections (very important in the tropics). Basic background on the immune apparatus in the intestine is also discussed, as are the effects of inflammation on intestinal permeability.

Immunology of Neuromuscular Disease

Immunology of Neuromuscular Disease PDF Author: Reinhard Hohlfeld
Publisher: Springer Science & Business Media
ISBN: 9401114226
Category : Medical
Languages : en
Pages : 299
Book Description
The neuromuscular diseases comprise the disorders of peripheral nerves, the neuromuscular junction, and muscle. Both pre and post-synaptic elements of the neuromuscular junction may become targets of autoimmune attack in different diseases. This book addresses the immunologically mediated neuromuscular diseases, including Guillain--Barré syndrome and other autoimmune neuropathies, the Lambert--Eaton myasthenic syndrome, myasthenia gravis, and the autoimmune diseases of muscle. Two chapters are devoted to the vasculitic and HIV-mediated neuromuscular diseases. The experimental models of neuritis and myasthenia gravis are addressed in separate chapters. An introductory chapter provides a general background to autoimmunity. This book is a useful overview for all neurologists, rheumatologists and immunologists both in research and clinical practice.

Immunology of Liver Disease

Immunology of Liver Disease PDF Author: H.C. Thomas
Publisher: Springer Science & Business Media
ISBN: 9401114285
Category : Medical
Languages : en
Pages : 209
Book Description
The role of the immune response in both the pathology of liver disease and in the modulation ofliver injury has been the subject of intense research. This book aims to present the current understanding of the involvement of the immune response in liver disease. The first chapters examine the role of the immune response in viral infections of the liver. These viruses cause hepatitis of varying severity and it is thought that many of the mechanisms responsible for liver cell injury are immunologically mediated. In addition three of these viruses, hepatitic B, C, and D, are associated with persistent infection and chronic liver disease. The role of the immune response in viral persistence is discussed. Further chapters are devoted to the three major autoimmune liver diseases which are thought to be the result of loss of tolerance to autologous liver tissue. There has been much recent research on cellular immune responses in these diseases but knowledge of the immunological processes which lead to the breakdown of tolerance and the mechanisms of tissue damage are limited. Other research has concentrated on the identification of the antigens which are the targets of this immune response. Linkage disequilibrium between MHC alleles and autoimmune diseases has suggested a role for immunogenetic factors.

Cancer Immunology

Cancer Immunology PDF Author: R.A. Robins
Publisher: Springer Science & Business Media
ISBN: 9401709637
Category : Medical
Languages : en
Pages : 253
Book Description
This publication provides a comprehensive account of the known groups of human tumour antigens, and the immune effector cells involved in tumour rejection. Chapters dealing with all the major groups of human tumour antigens are included, covering differentiation antigens, testes-associated antigens, CEA, mucin, viral antigens, anti-idiotypic antibodies as antigens, and fusion proteins. The role of heat shock proteins as mediators of tumour immunity is discussed and consideration is given to the immune mechanisms which mediate tumour rejection in both human and animal systems. The application of antibody targeting to identify cancers, and the mechanisms by which tumours evade immune detection and/or destruction is covered in detail. Although the focus of this publication is experimental, as with other recent publications progress in clinical immunotherapy is included in some detail, to provide postgraduate and post-doctoral scientists with in-depth reviews of the field.

Immunology of Infection

Immunology of Infection PDF Author: J.G. Sissons
Publisher: Springer Science & Business Media
ISBN: 9401114307
Category : Medical
Languages : en
Pages : 245
Book Description
The immune system has evolved in large part to enable organisms to resist microbial infection. Microorganisms have long been used as experimental tools by immunologists, and the study of the immune response to viruses and bacteria has contributed much to our understanding of basic immunological mechanisms. There are also important practical and clinical reasons for attempting to understand the immunology of infections -- these include the rational design of vaccines, the pathogenesis of infectious diseases, the advent of AIDS, the rise in drug-resistant mycobacterial infections and the recognition of the infectious aetiology of peptic ulcer disease. The contributors to this book are all chosen for their active involvement and expertise in the fields. It bridges the divide between basic immunological research and clinical practice.

Immunology of HIV Infection

Immunology of HIV Infection PDF Author: Gr. Bird
Publisher: Springer Science & Business Media
ISBN: 9401129800
Category : Medical
Languages : en
Pages : 180
Book Description
It is now 10 years since the first AIDS cases were reported in the USA. In that relatively short period of time, study of the disease has moved from the level of early clinical description to exhaustive and extensive laboratory characterization of the human immunodeficiency virus (HIV), the immune responses directed towards it and reasons for their failure. This volume provides contributions from clinical and basic scientists who are actively involved in research in a number of areas of current interest and controversy. Further progress in the clinical management of the HIV-infected patient will undoubtedly build on the basic knowledge about HIV and its modes of pathogenesis. The intimate relationship between HIV and the human immune system provides observations and questions that are relevant to viral immunopathogenesis in general. In the first chapter the clinical features of HIV immunodeficiency are re viewed, and aspects of its changing face are discussed. Dr Tersmette then presents evidence for changing viral characteristics at different stages of the disease. This view of close competition for ascendancy between HIV and the host immune response raises questions about current approaches to therapy.

Immunological Aspects of Gastroenterology

Immunological Aspects of Gastroenterology PDF Author: Y.R. Mahida
Publisher: Springer Science & Business Media
ISBN: 940100790X
Category : Medical
Languages : en
Pages : 359
Book Description
Diseases of the gastrointestinal tract are common. There is increasing appreciation of the importance of the immune system in the pathogenesis of a number of these diseases. This book covers basic aspects of innate and adaptive immunity in the gastrointestinal tract, oral tolerance, and cellular and molecular mechanisms of acute and chronic inflammation. Specific disease covered include bacterial infections, human immunodeficiency virus (HIV) infection, coeliac disease, and inflammatory bowel disease. Other topics include mucosal immunisation and intestinal transplantation immunology. The readership of this book includes clinicians, scientists, and students interested in the gastrointestinal tract.