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Bayesian Methods in Health Economics

Bayesian Methods in Health Economics PDF Author: Gianluca Baio
Publisher: CRC Press
ISBN: 1439895554
Category : Mathematics
Languages : en
Pages : 246

Book Description
Health economics is concerned with the study of the cost-effectiveness of health care interventions. This book provides an overview of Bayesian methods for the analysis of health economic data. After an introduction to the basic economic concepts and methods of evaluation, it presents Bayesian statistics using accessible mathematics. The next chapters describe the theory and practice of cost-effectiveness analysis from a statistical viewpoint, and Bayesian computation, notably MCMC. The final chapter presents three detailed case studies covering cost-effectiveness analyses using individual data from clinical trials, evidence synthesis and hierarchical models and Markov models. The text uses WinBUGS and JAGS with datasets and code available online.

Bayesian Methods in Health Economics

Bayesian Methods in Health Economics PDF Author: Gianluca Baio
Publisher: CRC Press
ISBN: 1439895554
Category : Mathematics
Languages : en
Pages : 246
Book Description
Health economics is concerned with the study of the cost-effectiveness of health care interventions. This book provides an overview of Bayesian methods for the analysis of health economic data. After an introduction to the basic economic concepts and methods of evaluation, it presents Bayesian statistics using accessible mathematics. The next chapters describe the theory and practice of cost-effectiveness analysis from a statistical viewpoint, and Bayesian computation, notably MCMC. The final chapter presents three detailed case studies covering cost-effectiveness analyses using individual data from clinical trials, evidence synthesis and hierarchical models and Markov models. The text uses WinBUGS and JAGS with datasets and code available online.

Bayesian Cost-Effectiveness Analysis of Medical Treatments

Bayesian Cost-Effectiveness Analysis of Medical Treatments PDF Author: Elias Moreno
Publisher: CRC Press
ISBN: 1351744364
Category : Mathematics
Languages : en
Pages : 217
Book Description
Cost-effectiveness analysis is becoming an increasingly important tool for decision making in the health systems. Cost-Effectiveness of Medical Treatments formulates the cost-effectiveness analysis as a statistical decision problem, identifies the sources of uncertainty of the problem, and gives an overview of the frequentist and Bayesian statistical approaches for decision making. Basic notions on decision theory such as space of decisions, space of nature, utility function of a decision and optimal decisions, are explained in detail using easy to read mathematics. Features Focuses on cost-effectiveness analysis as a statistical decision problem and applies the well-established optimal statistical decision methodology. Discusses utility functions for cost-effectiveness analysis. Enlarges the class of models typically used in cost-effectiveness analysis with the incorporation of linear models to account for covariates of the patients. This permits the formulation of the group (or subgroup) theory. Provides Bayesian procedures to account for model uncertainty in variable selection for linear models and in clustering for models for heterogeneous data. Model uncertainty in cost-effectiveness analysis has not been considered in the literature. Illustrates examples with real data. In order to facilitate the practical implementation of real datasets, provides the codes in Mathematica for the proposed methodology. The motivation for the book is to make the achievements in cost-effectiveness analysis accessible to health providers, who need to make optimal decisions, to the practitioners and to the students of health sciences. Elías Moreno is Professor of Statistics and Operational Research at the University of Granada, Spain, Corresponding Member of the Royal Academy of Sciences of Spain, and elect member of ISI. Francisco José Vázquez-Polo is Professor of Mathematics and Bayesian Methods at the University of Las Palmas de Gran Canaria, and Head of the Department of Quantitative Methods. Miguel Ángel Negrín is Senior Lecturer in the Department of Quantitative Methods at the ULPGC. His main research topics are Bayesian methods applied to Health Economics, economic evaluation and cost-effectiveness analysis, meta-analysis and equity in the provision of healthcare services.

Bayesian Methods in Pharmaceutical Research

Bayesian Methods in Pharmaceutical Research PDF Author: Emmanuel Lesaffre
Publisher: CRC Press
ISBN: 1351718665
Category : Medical
Languages : en
Pages : 561
Book Description
Since the early 2000s, there has been increasing interest within the pharmaceutical industry in the application of Bayesian methods at various stages of the research, development, manufacturing, and health economic evaluation of new health care interventions. In 2010, the first Applied Bayesian Biostatistics conference was held, with the primary objective to stimulate the practical implementation of Bayesian statistics, and to promote the added-value for accelerating the discovery and the delivery of new cures to patients. This book is a synthesis of the conferences and debates, providing an overview of Bayesian methods applied to nearly all stages of research and development, from early discovery to portfolio management. It highlights the value associated with sharing a vision with the regulatory authorities, academia, and pharmaceutical industry, with a view to setting up a common strategy for the appropriate use of Bayesian statistics for the benefit of patients. The book covers: Theory, methods, applications, and computing Bayesian biostatistics for clinical innovative designs Adding value with Real World Evidence Opportunities for rare, orphan diseases, and pediatric development Applied Bayesian biostatistics in manufacturing Decision making and Portfolio management Regulatory perspective and public health policies Statisticians and data scientists involved in the research, development, and approval of new cures will be inspired by the possible applications of Bayesian methods covered in the book. The methods, applications, and computational guidance will enable the reader to apply Bayesian methods in their own pharmaceutical research.

Statistical Topics in Health Economics and Outcomes Research

Statistical Topics in Health Economics and Outcomes Research PDF Author: Demissie Alemayehu, PhD
Publisher: CRC Press
ISBN: 1498781888
Category : Mathematics
Languages : en
Pages : 190
Book Description
With ever-rising healthcare costs, evidence generation through Health Economics and Outcomes Research (HEOR) plays an increasingly important role in decision-making about the allocation of resources. Accordingly, it is now customary for health technology assessment and reimbursement agencies to request for HEOR evidence, in addition to data from clinical trials, to inform decisions about patient access to new treatment options. While there is a great deal of literature on HEOR, there is a need for a volume that presents a coherent and unified review of the major issues that arise in application, especially from a statistical perspective. Statistical Topics in Health Economics and Outcomes Research fulfils that need by presenting an overview of the key analytical issues and best practice. Special attention is paid to key assumptions and other salient features of statistical methods customarily used in the area, and appropriate and relatively comprehensive references are made to emerging trends. The content of the book is purposefully designed to be accessible to readers with basic quantitative backgrounds, while providing an in-depth coverage of relatively complex statistical issues. The book will make a very useful reference for researchers in the pharmaceutical industry, academia, and research institutions involved with HEOR studies. The targeted readers may include statisticians, data scientists, epidemiologists, outcomes researchers, health economists, and healthcare policy and decision-makers.

Bayesian Cost-Effectiveness Analysis with the R package BCEA

Bayesian Cost-Effectiveness Analysis with the R package BCEA PDF Author: Gianluca Baio
Publisher: Springer
ISBN: 9783319557168
Category : Medical
Languages : en
Pages : 168
Book Description
The book provides a description of the process of health economic evaluation and modelling for cost-effectiveness analysis, particularly from the perspective of a Bayesian statistical approach. Some relevant theory and introductory concepts are presented using practical examples and two running case studies. The book also describes in detail how to perform health economic evaluations using the R package BCEA (Bayesian Cost-Effectiveness Analysis). BCEA can be used to post-process the results of a Bayesian cost-effectiveness model and perform advanced analyses producing standardised and highly customisable outputs. It presents all the features of the package, including its many functions and their practical application, as well as its user-friendly web interface. The book is a valuable resource for statisticians and practitioners working in the field of health economics wanting to simplify and standardise their workflow, for example in the preparation of dossiers in support of marketing authorisation, or academic and scientific publications.

Statistical Methods for Healthcare Performance Monitoring

Statistical Methods for Healthcare Performance Monitoring PDF Author: Alex Bottle
Publisher: CRC Press
ISBN: 1482246104
Category : Mathematics
Languages : en
Pages : 269
Book Description
Healthcare is important to everyone, yet large variations in its quality have been well documented both between and within many countries. With demand and expenditure rising, it’s more crucial than ever to know how well the healthcare system and all its components – from staff member to regional network – are performing. This requires data, which inevitably differ in form and quality. It also requires statistical methods, the output of which needs to be presented so that it can be understood by whoever needs it to make decisions. Statistical Methods for Healthcare Performance Monitoring covers measuring quality, types of data, risk adjustment, defining good and bad performance, statistical monitoring, presenting the results to different audiences and evaluating the monitoring system itself. Using examples from around the world, it brings all the issues and perspectives together in a largely non-technical way for clinicians, managers and methodologists. Statistical Methods for Healthcare Performance Monitoring is aimed at statisticians and researchers who need to know how to measure and compare performance, health service regulators, health service managers with responsibilities for monitoring performance, and quality improvement scientists, including those involved in clinical audits.

Benefit-Risk Assessment Methods in Medical Product Development

Benefit-Risk Assessment Methods in Medical Product Development PDF Author: Qi Jiang
Publisher: CRC Press
ISBN: 1482259370
Category : Mathematics
Languages : en
Pages : 296
Book Description
Guides You on the Development and Implementation of B–R Evaluations Benefit–Risk Assessment Methods in Medical Product Development: Bridging Qualitative and Quantitative Assessments provides general guidance and case studies to aid practitioners in selecting specific benefit–risk (B–R) frameworks and quantitative methods. Leading experts from industry, regulatory agencies, and academia present practical examples, lessons learned, and best practices that illustrate how to conduct structured B–R assessment in clinical development and regulatory submission. The first section of the book discusses the role of B–R assessments in medicine development and regulation, the need for both a common B–R framework and patient input into B–R decisions, and future directions. The second section focuses on legislative and regulatory policy initiatives as well as decisions made at the U.S. FDA’s Center for Devices and Radiological Health. The third section examines key elements of B–R evaluations in a product’s life cycle, such as uncertainty evaluation and quantification, quantifying patient B–R trade-off preferences, ways to identify subgroups with the best B–R profiles, and data sources used to assist B–R assessment. The fourth section equips practitioners with tools to conduct B–R evaluations, including assessment methodologies, a quantitative joint modeling and joint evaluation framework, and several visualization tools. The final section presents a rich collection of case studies. With top specialists sharing their in-depth knowledge, thought-provoking considerations, and practical advice, this book offers comprehensive coverage of B–R evaluation methods, tools, and case studies. It gives practitioners a much-needed toolkit to develop and conduct their own B–R evaluations.

Statistical Analysis of Cost-Effectiveness Data

Statistical Analysis of Cost-Effectiveness Data PDF Author: Andrew R. Willan
Publisher: John Wiley & Sons
ISBN: 0470856270
Category : Mathematics
Languages : en
Pages : 210
Book Description
The statistical analysis of cost-effectiveness data is becoming increasingly important within health and medical research. Statistical Analysis of Cost-Effectiveness Data provides a practical book that synthesises the huge amount of research that has taken place in the area over the last two decades. Comprising an up-to-date overview of the statistical analysis of cost-effectiveness data, the book is supported by numerous worked examples from the author’s own experience. It has been written in a style suitable for medical statisticians and health care professionals alike. Key features include: an overview of statistical methods used in the analysis of cost-effectiveness data. coverage of Bayesian methodology. illustrated throughout by worked examples using real data. suitability for health care professionals with limited statistical knowledge. discussion of software used for data analysis. An essential reference for biostatisticians and health economists engaged in cost-effectiveness analysis of health-care interventions, both in academia and industry. Also of interest to graduate students of biostatistics, public health and economics.

Design & Analysis of Clinical Trials for Economic Evaluation & Reimbursement

Design & Analysis of Clinical Trials for Economic Evaluation & Reimbursement PDF Author: Iftekhar Khan
Publisher: CRC Press
ISBN: 1466505486
Category : Mathematics
Languages : en
Pages : 339
Book Description
Economic evaluation has become an essential component of clinical trial design to show that new treatments and technologies offer value to payers in various healthcare systems. Although many books exist that address the theoretical or practical aspects of cost-effectiveness analysis, this book differentiates itself from the competition by detailing

The Dictionary of Health Economics, Second Edition

The Dictionary of Health Economics, Second Edition PDF Author: Anthony J. Culyer
Publisher: Edward Elgar Publishing
ISBN: 1849806624
Category : Medical
Languages : en
Pages : 712
Book Description
''Another masterpiece in health economics from a doyen in the field, this expanded and updated dictionary will undoubtedly become a standard reference work for scholars, practitioners and others working in this area. The definitions are concise, the coverage is comprehensive, the cross-referencing is excellent, and the subject and name indexes greatly assist navigation of this substantial tome. You will want to keep this one within arm''s reach.'' Jim Butler, Australia National University ''Health economics and health service research as well as health care policy, delivery and finance rely on a dizzying array of terms drawn from a diverse set of disciplines including (but not limited) to economics, epidemiology, risk science and statistics. Moreover, the health and health care systems are replete with acronyms and specialized institutions. The Dictionary of Health Economics provides the most comprehensive set of definitions and explanations of these terms available. It is a fantastic resource for anyone working in any health related field.'' Michael Chernew, Harvard Medical School, US ''This dictionary is unique. What other dictionary borders on being an enjoyable read? Its breadth is quite astonishing. It is also very clearly a health economics dictionary and will allow those in mainstream economics, in the other social sciences and in health sciences and health care to understand and be better able to communicate with health economists. It will also be a most useful addition to the bookshelves of health economists like myself.'' Gavin Mooney, University of Sydney, Australia ''This book is a welcome addition for graduate students or professionals interested in the taxonomy of health care.'' David Cutler, Harvard University, US ''Health economics is at the crossroads of medicine, economics, statistics, insurance, and the law. This often makes for difficult reading. But help is now available thanks to this amazingly comprehensive Dictionary of Health Economics. I for one ran into several entries that I did not or did not fully understand, but the very clear explanations changed that within a few moments! This Dictionary is a true service to the scientific community.'' Peter Zweifel, University of Zurich, Switzerland ''The Dictionary provides a comprehensive overview and authoritative yet accessible explanation of important terms and concepts from the increasingly important field of health economics. This excellent work will enable many entering this field, students and professionals alike, to quickly yet thoroughly grasp the meaning of the health economics jargon, facilitating study and (multi-disciplinary) co-operation. Anthony Culyer is sharing his impressive knowledge in this field in a clear and user-friendly fashion, hopefully to the benefit of many readers.'' Werner Brouwer, Erasmus University Rotterdam, the Netherlands ''An essential book to steer the student away from a minefield of inaccurate and woolly definitions and an important resource of the practitioner of health economics. A book that offers the reader accuracy and rigour in the definitions it provides of key terms in health economics alongside ready access.'' John Brazier, University of Sheffield, UK This second edition of Culyer''s authoritative Dictionary of Health Economics brings the material up to date and adds large amounts of new information. Some definitions have been revised. There are over 700 new entries. The Dictionary now also contains extensive references to the literature to identify original source material or to provide illustrations of the headword in use. The bibliography comprises some 1,000 items. In view of the huge growth in cost-effectiveness studies and the continuing variability in their quality, an appendix lists 100 high quality cost-effectiveness studies from all parts of the world. There are now many more entries and references relating to the developing world. New and separate subject and name indices provide supplementary means of searching the material and identifying individuals who have contributed significantly to the oeuvre.